Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

Outline

Fig. 04 -

Stable Hypercapnic COPD

Fig. 05 -

Hypoxic and Hypercapnic

Fig. 06 -

Oxygen vs Mechanical

Fig. 07 -

Domiciliary Ventilation

Fig. 08 -

Eurovent Survey

Fig. 09 -

High-intensity vs Low-intensity

Fig. 10 -

Aim of Ventilation

Fig. 11 -

Guidelines - COPD Failure

Fig. 12 -

Reduce Baseline PaCO2

Fig. 13 -

Kohnlein Clinical Trial

Fig. 14 -

Exercise Capacity

Fig. 15 -

Health Related Quality of Life

Fig. 16 -

Mortality Rate Reduction

Fig. 17 -

Benefits of Proper Use

Fig. 18 -

Patients Eligible for NIV

Fig. 19 -

Reduce Exacerbation Frequency

Fig. 20 -

Non-invasive Positive Pressure Ventilation

Fig. 21 -

Outcomes: 1998-2008

Fig. 22 -

What Happens Post Discharge?

Fig. 23 -

Probability of Survival Post NIV

Fig. 24 -

Long-term Survival Post NIV

Fig. 25 -

Probability of Readmission Post NIV

Fig. 26 -

Home based NIV and Rehospitalization

Fig. 27 -

NIV Study: Pilot Trial

Fig. 28 -

Retrospective Analysis

Fig. 29 -

The Rescue Trial

Fig. 30 -

Randomization

Fig. 31 -

Primary Outcome Results

Fig. 32 -

Reduction of PaCO2 over time

Fig. 33 -

Future Studies

Fig. 34 -

HOT HMV Trial

Fig. 35 -

A Proof-of-Concept Study

Fig. 36 -

Can a exacerbation be predicted

Fig. 37 -

Facilitate Exercise Capacity

Fig. 38 -

Nocturnal NIV & Rehabilitation

Fig. 39 -

1. Randomized Controlled Trial

Fig. 40 -

2. Randomized Controlled Trial

Fig. 41 -

Activity Restriction

Fig. 42 -

Randomized Cross-over Trial

Fig. 43 -

Summary I

Fig. 44 -

Summary II

Fig. 45 -

Closing