Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

How This Started

Fig. 04 -

Timeline

Fig. 05 -

Hypothesis

Fig. 06 -

UK Survival AECOPD

Fig. 07 -

4-6 Weeks

Fig. 08 -

12 Months

Fig. 09 -

Median Time

Fig. 10 -

Trial Design

Fig. 11 -

HOT-HMV Trial

Fig. 12 -

High Likelihood

Fig. 13 -

Following Resolution

Fig. 14 -

Cost Effective Manner

Fig. 15 -

Clear End-Point

Fig. 16 -

Target Population

Fig. 17 -

Baseline Characteristics

Fig. 18 -

Hot HMV & Hot

Fig. 19 -

Severe COPD

Fig. 20 -

Limited Treatment Options

Fig. 21 -

To Sick to Respond

Fig. 22 -

Recruitment

Fig. 23 -

16 Percent

Fig. 24 -

39 Percent

Fig. 25 -

16 Percent Discharged

Fig. 26 -

11 Percent

Fig. 27 -

26 Percent

Fig. 28 -

Persistent Hypercapnia

Fig. 29 -

Patients Recruited

Fig. 30 -

Intervention and Control

Fig. 31 -

HOT-HMV vs HOT

Fig. 32 -

Key Considerations

Fig. 33 -

12 Month Admission-Free

Fig. 34 -

Titration of NIV

Fig. 35 -

HOT & Home NIV

Fig. 36 -

Mean Difference

Fig. 37 -

Blood Gas Measurements

Fig. 38 -

Within Group Change

Fig. 39 -

Hot Arm Changed

Fig. 40 -

Admission Free Survival

Fig. 41 -

What?

Fig. 42 -

Reduced Readmission

Fig. 43 -

6 to 1 Ratio

Fig. 44 -

Secondary Outcome

Fig. 45 -

No Detrimental

Fig. 46 -

Acute Exacerbation Rate

Fig. 47 -

One Third Reduction

Fig. 48 -

28 Day Group Benefits

Fig. 49 -

Early Portion

Fig. 50 -

Separation of Treatment

Fig. 51 -

Two Third Reductions

Fig. 52 -

Comparison

Fig. 53 -

Thorax 2014

Fig. 54 -

Rescue vs Hot-HMV

Fig. 55 -

How?

Fig. 56 -

Persisting Hypercapnia

Fig. 57 -

Treatment with HOT-HMV

Fig. 58 -

Chronic Respiratory Failure

Fig. 59 -

Exacerbation Frequency

Fig. 60 -

Hypercapnia Decreases Secretion

Fig. 61 -

28-day Readmission

Fig. 62 -

Enhanced Health

Fig. 63 -

Effect on Readmission

Fig. 64 -

Clinical Implication

Fig. 65 -

Partial Summary

Fig. 66 -

Clinical Practice Change

Fig. 67 -

Continued Partial Summary

Fig. 68 -

With thanks to….

Fig. 69 -

The patients

Fig. 70 -

Team and Network

Fig. 71 -

Funders and Sponsors

Fig. 72 -

Research Group and Sponsors

Fig. 73 -

Thank You