Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

What is a D-dimer

Fig. 04 -

What diagnoses

Fig. 05 -

Who needs a workup

Fig. 06 -

What is the role

Fig. 07 -

Aortic Dissection

Fig. 08 -

Limitations

Fig. 09 -

Positive D-dimer

Fig. 10 -

What is a D-dimer

Fig. 11 -

Activation and Fibrinolysis

Fig. 12 -

D-dimer Diagnoses

Fig. 13 -

Venous Thromboembolism

Fig. 14 -

Deep VT vs Pulm. Emb.

Fig. 15 -

CT Scan

Fig. 16 -

Epidemiology

Fig. 17 -

Spectrum of Severity

Fig. 18 -

VTE Incidence

Fig. 19 -

Rare and Fatal

Fig. 20 -

Workup for VTE

Fig. 21 -

Risk Factors

Fig. 22 -

Symptoms and Signs

Fig. 23 -

Threshold Analysis

Fig. 24 -

Test Threshold

Fig. 25 -

PERC

Fig. 26 -

PERC - Chart

Fig. 27 -

Probability and Bayesian Analysis

Fig. 28 -

Probability and Bayesian Analysis (Cont.)

Fig. 29 -

Role in VTE workup

Fig. 30 -

DVT and PE: Sensitivity

Fig. 31 -

DVT and PE: Negative

Fig. 32 -

DVT

Fig. 33 -

Bayesian Analysis

Fig. 34 -

Prevalence of PE

Fig. 35 -

Clinical Use

Fig. 36 -

Non-Invasive, Non-Ionizing

Fig. 37 -

Role in Aortic Dissection

Fig. 38 -

Pooled Sensitivity and Negative LR

Fig. 39 -

Limitations of Testing

Fig. 40 -

Limitations of D-dimer

Fig. 41 -

Age

Fig. 42 -

Cancer

Fig. 43 -

Pregnancy

Fig. 44 -

Immobilization

Fig. 45 -

Surgery

Fig. 46 -

Medical Co-Morbidities

Fig. 47 -

Patients with Prior VTE

Fig. 48 -

Increased Testing

Fig. 49 -

Adjusting Threshold

Fig. 50 -

"Missed PE"

Fig. 51 -

Age Adjusted

Fig. 52 -

Pregnancy Adjusted

Fig. 53 -

After a Positive D-dimer

Fig. 54 -

Diagnostic Algorithm

Fig. 55 -

CT Pulmonary Angiography

Fig. 56 -

CT Pulmonary Angiography (Cont.)

Fig. 57 -

Summary 1

Fig. 58 -

Summary II

Fig. 59 -

Summary III

Fig. 60 -

Summary IV

Fig. 61 -

Powerful

Fig. 62 -

Thank You