Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

Sleep Disordered Breathing

Fig. 04 -

Airway Obstruction

Fig. 05 -

CPAP

Fig. 06 -

National Commission

Fig. 07 -

Sleep Cohort Study

Fig. 08 -

Prevalence

Fig. 09 -

Comorbidity

Fig. 10 -

OSA in CVD Patients

Fig. 11 -

Mechanisms of Disease

Fig. 12 -

Needle & Electrode

Fig. 13 -

Awake

Fig. 14 -

Stages

Fig. 15 -

Airflow

Fig. 16 -

Awake, CPAP-REM, OSA-REM

Fig. 17 -

Vagal Activation

Fig. 18 -

Diving Reflex

Fig. 19 -

Autonomic Response

Fig. 20 -

Adhesion Molecules

Fig. 21 -

Effect of Monocytes

Fig. 22 -

Increased CRP

Fig. 23 -

OSA Linkages to Cardio Diseases

Fig. 24 -

Hypertension

Fig. 25 -

Increased Levels

Fig. 26 -

Odds Ratios

Fig. 27 -

Joint National Committe

Fig. 28 -

Changes in Blood Pressure

Fig. 29 -

Meta-Analysis

Fig. 30 -

Effect of CPAP

Fig. 31 -

Resistant Hypertension

Fig. 32 -

Unrecognized Sleep Apnea

Fig. 33 -

HIPARCO

Fig. 34 -

Atrial Fibrillation

Fig. 35 -

Increased CRP

Fig. 36 -

Clinical Investigation and Reports

Fig. 37 -

OSA, Structure & Function

Fig. 38 -

Pathophysiology

Fig. 39 -

OSA Status

Fig. 40 -

OSA Severity

Fig. 41 -

Prevalence

Fig. 42 -

Recurrence of Afib

Fig. 43 -

Afib Recurrence

Fig. 44 -

Myocardial Ischemia and Infarction

Fig. 45 -

Awake, CPAP-Rem & OSA-Rem

Fig. 46 -

Sleep Apnea & Nocturnal Angina

Fig. 47 -

Nocturnal Oxygen & ST-depression

Fig. 48 -

Day-Night Variation of MI

Fig. 49 -

Day-Night Pattern of MI

Fig. 50 -

Hypoxemia and Prognosis

Fig. 51 -

Sudden Cardiac Death

Fig. 52 -

Mayo Sleep Disorders Center

Fig. 53 -

Day-Night Pattern of SCD

Fig. 54 -

Usual Sleep-Wake Cycles

Fig. 55 -

Rate of SCD

Fig. 56 -

Numbers at Risk

Fig. 57 -

Conclusions

Fig. 58 -

Review