Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

Hypotheses

Fig. 04 -

Obstructive Hypopnea

Fig. 05 -

Effect of Obstructive Apneas

Fig. 06 -

Central Apnea

Fig. 07 -

Effect of Central Apneas

Fig. 08 -

Stroke Volume

Fig. 09 -

Influence of OSA

Fig. 10 -

Effects of CPAP

Fig. 11 -

Patients with HF

Fig. 12 -

LVEF and Fractional Shortening

Fig. 13 -

MSNA Bursts/Min

Fig. 14 -

Survival in HF

Fig. 15 -

Sleepiness and Sleep Structure

Fig. 16 -

RCT

Fig. 17 -

Conclusions

Fig. 18 -

Conclusions (Cont.)

Fig. 19 -

Transplant Free Survival

Fig. 20 -

Effects of CPAP on TFS

Fig. 21 -

TFS on CSA

Fig. 22 -

Conclusions

Fig. 23 -

ADVENT-HF

Fig. 24 -

Study Sites

Fig. 25 -

Comparison

Fig. 26 -

SERVE-HF Trial Design 1

Fig. 27 -

SERVE-HF Trial Design 2

Fig. 28 -

SERVE-HF Trial Design 3

Fig. 29 -

SERVE-HF Trial Results 1

Fig. 30 -

SERVE-HF Trial Results 2

Fig. 31 -

SERVE-HF Trial Results 3

Fig. 32 -

ADVENT-HF: Trial Design 1

Fig. 33 -

ADVENT-HF: Trial Design 2

Fig. 34 -

ADVENT-HF: Trial Design 3

Fig. 35 -

Differences and Importance

Fig. 36 -

Progress

Fig. 37 -

Baseline Demographic Data

Fig. 38 -

Cardiomyopathy

Fig. 39 -

NYHA Classes

Fig. 40 -

Sleep Apnea and LVEF Data

Fig. 41 -

More Challenges

Fig. 42 -

One Step at a Time!