- Figure 20
Effects of CPAP on Transplant-free Survival
FIG. 20: The Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure (CanPAP) trial randomized patients with systolic heart failure and CSA to no treatment for their apnea or to CPAP and followed them for a period of up to 5 years.[10] This Figure shows the transplant-free survival versus time. After randomization it is apparent that in the first 18 months, the group randomized to CPAP actually did worse than the control group, but later that changed, so that the CPAP group was doing better than the control group by the end of the trial. However, the total number of events in each group was the same, at 32, so there was no significant difference between the two groups.
This suggests is that there are two groups of patients: patients who received CPAP and responded, and a group who received CPAP but did not respond.
References
Bradley TD, Logan AG, Kimoff RJ, et al; CANPAP Investigators. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med. 2005;353:2025–2033.
