FIG. 34:  This Figure outlines the primary endpoint (see also Figure 23).^[12]  An important aspect of ADVENT-HF is that the patients are more closely monitored than those in SERVE-HF, with follow-up every 6 months rather than every year, and the DSMB examines outcome data every 6 months.  There have been 4 DSMB reviews to date and no concerns about patient safety have been identified.