Witjes - Figure 18
Prediction of BCG responders
FIG. 18: Dr Kamat and colleagues reported last year[7] that a combination of 9 cytokines correlated very well with response to BCG, with an accuracy of almost 90%. Another study]8] found that another cytokine, fibroblast growth factor receptor 3 (FGFR3), is predictive of the response to BCG.
References
Kamat AM, Briggman J, Urbauer DL, et al. Cytokine Panel for Response to Intravesical Therapy (CyPRIT): Nomogram of changes in urinary cytokine levels predicts patient response to bacillus Calmette-Guérin. Eur Urol. 2016;69:197−200 http://dx.doi.org/10.1016/j.eururo.2015.06.023
Langle YV, Belgorosky D, Prack McCormick B, et al. FGFR3 down-regulation is involved in bacillus Calmette-Guérin induced bladder tumor growth inhibition. J Urol. 2016;195:188−97 http://dx.doi.org/10.1016/j.juro.2015.06.093