Witjes - Figure 24
Combination therapy with BCG
FIG. 24: In theory, combining intravesical chemotherapy and intravesical BCG might be more effective, because giving intravesical chemotherapy first will promote the reaction of BCG. We did a study that found slightly greater efficacy and a few more side effects with combination therapy (mitomycin and BCG), but the differences were not statistically significant compared with mitomycin alone.[12]
References
[12]
Witjes JA, Caris CT, Mungan NA, et al. Results of a randomized phase III trial of sequential intravesical therapy with mitomycin C and bacillus Calmette-Guerin versus mitomycin C alone in patients with superficial bladder cancer. J Urol. 1998;160:1668−71 http://dx.doi.org/10.1016/S0022-5347(01)62377-2