Witjes - Figure 24

Combination therapy with BCG

FIG. 24:  In theory, combining intravesical chemotherapy and intravesical BCG might be more effective, because giving intravesical chemotherapy first will promote the reaction of BCG.  We did a study that found slightly greater efficacy and a few more side effects with combination therapy (mitomycin and BCG), but the differences were not statistically significant compared with mitomycin alone.[12]

References

[12]

Witjes JA, Caris CT, Mungan NA, et al. Results of a randomized phase III trial of sequential intravesical therapy with mitomycin C and bacillus Calmette-Guerin versus mitomycin C alone in patients with superficial bladder cancer. J Urol. 1998;160:1668−71  http://dx.doi.org/10.1016/S0022-5347(01)62377-2