Witjes - Figure 46
Does the BCG strain matter?
FIG. 46: Other BCG strains have been investigated in bladder cancer studies. An attenuated, live culture preparation of Mycobacterium bovis (BCG Tice) and BCG RIVM, a Dutch preparation, were compared vs mitomycin in patients with pTa and pT1 bladder tumors.[38] Although there was little difference between the other 2 strains, BCG Tice was the least effective, with more recurrences. A Swiss study that compared BCG Tice with BCG Connaught showed that BCG Tice was significantly less effective with respect to recurrence rate.[39]
References
Vegt PD, Witjes JA, Witjes WP, et al. A randomized study of intravesical mitomycin C, bacillus Calmette-Guerin Tice and bacillus Calmette-Guerin RIVM treatment in pTa-pT1 papillary carcinoma and carcinoma in situ of the bladder. J Urol. 1995;153:929−33 http://dx.doi.org/10.1016/S0022-5347(01)67606-7
Rentsch CA, Birkhäuser FD, Biot C, et al. Bacillus Calmette-Guérin strain differences have an impact on clinical outcome in bladder cancer immunotherapy. Eur Urol. 2014;66:677−88 http://dx.doi.org/10.1016/j.eururo.2014.02.061
