Witjes - Figure 56
Thermosensitive hydrogel
FIG. 56: Reverse thermosensitive hydrogels are in development that exist as fluid at cold temperatures and solidify to a gel at body temperature. Mitomycin C can be dissolved in this type of gel, potentially increasing the level of drug in the bladder tissue. Clinical studies are underway to demonstrates that this type of slow-release option offers another way to promote the effect of mitomycin.[45,46]
References
Pre-TURBT TC-3 Gel Intravesical Instillation in NMIBC (OPTIMA). ClinicalTrials.gov Identifier: NCT01803295. June 15, 2017 https://clinicaltrials.gov/ct2/show/NCT01803295 Accessed August 6, 2017
The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study (Olympus). ClinicalTrials.gov Identifier: NCT02793128. July 27, 2017 https://clinicaltrials.gov/ct2/show/NCT02793128 Accessed August 6, 2017
