Stenzl - Figure 15

Molecular profiling in T1 tumors - is molecular subclassification the main driver for therapeutic strategy?

FIG. 15:  One of the clinical applications of molecular profiling is decision-making in T1 tumors.  In those tumors this is already an infiltration into the submucosa but not yet into the muscularis, and we know that these tumors can be eradicated with a local excision plus an adjuvant treatment, most of the time with application of immunotherapy. On the other hand, T1 tumors can be very aggressive and can then lead to eventual development of metastases.