Stenzl - Figure 25

Molecular Subtypes in pre-TURB Samples by 4 Subtyping Methods

FIG. 25:  This Figure summarizes the various subclassification systems currently available, as outlined above.[2-5]  Whether the system classifies specimens as basal or cluster III/IV or squamous carcinoma-like cells or, on the other spectrum, whether they are classified as luminal or cluster I/II or basal A tumors, these two types of tumors are definitely different from one other.[19] There are, of course, some subdivisions (subclassifications) within each group, depending on the infiltration or on the epithelial-mesenchymal transition (EMT) activity and the claudin-low breast cancer-based classification, for example, in the UNC classification.[4]

References

[2]

The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014:507:315−22  nature.com/doifinder/10.1038/nature12965

[3]

Sjödahl G, Lauss M, Lövgren K, Chebil G, et al. A molecular taxonomy for urothelial carcinoma. Clin Cancer Res. 2012;18:3377−86  https://doi.org/10.1158/1078-0432.CCR-12-0077-T

[4]

Damrauer JS, Hoadley KA, Chism DD, et al. Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology. Proc Natl Acad Sci U S A. 2014;25:3110–5  https://doi.org/10.1073/pnas.1318376111

[5]

Choi W, Porten S, Kim S, et al. Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. Cancer Cell. 25, 152–65  http://dx.doi.org/10.1016/j.ccr.2014.01.009

[19]

Seiler R, Ashab HA, Erho N, et al. Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy. Eur Urol. Published online April 5, 2017  http://dx.doi.org/10.1016/j.eururo.2017.03.030