Shariat - Figure 22
EORTC Risk Tables and T1 Grade-3 Cancer
FIG. 22: The negative prognostic outlook for carcinoma in situ has been documented in a many studies of patients with T1 bladder cancer. One of these was the EORTC risk group tables from the group of Sylvester et al,[27] which showed that patients with T1 high-grade bladder cancers who have CIS have a 5-year progression rate of >45%.
The limitations of the studies were that they were based on old series with no re-TUR and no BCG, or only in a subgroup. Nevertheless, CIS does consistently confer a worse prognosis in patients with T1 bladder cancer.
References
Sylvester RJ, van der Meijden AP, Oosterlinck W, et al. Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol. 2006;49:466−77 https://doi.org/10.1016/j.eururo.2005.12.031
