Shariat - Figure 23
CIS in Prostatic Urethra and Female Gender as Independent Predictors of T1 High-grade Cancer Progression
FIG. 23: A study by Joan Palou and colleagues in Barcelona[28] showed that CIS in the prostatic urethra has a worse prognosis than CIS in the bladder, and that some patients with CIS in the bladder, like T1 bladder cancer, can be well treated and respond quite effectively to BCG intravesical therapy. One other demographic that seems to be a consistently negative predictive factor is female gender, which confers worse outcomes across all series. This may be due to a difference in biology, a difference in care administered, or delay in diagnosis.
References
Palou J, Sylvester RJ, Faba OR, et al. Female gender and carcinoma in situ in the prostatic urethra are prognostic factors for recurrence, progression, and disease-specific mortality in T1G3 bladder cancer patients treated with bacillus Calmette-Guérin. Eur Urol. 2012;62:118−25 http://dx.doi.org/10.1016/j.eururo.2011.10.029
