Shariat - Figure 31
Prognostic Value of the Lymphovascular Invasion
FIG. 31: One variable that I consider important in determining the natural history and risk of disease progression and cancer spread in T1 bladder cancer is the presence of lymphovascular invasion. All 3 major guidelines for NMI bladder cancer stipulate that pathologists should report on this variable.[17-19] In a study by Branchereau et al[38] (Figure) of 108 patients with high-grade T1 bladder cancer, the presence of lymphovascular invasion conferred a significantly worse outcome, whether treated with other TURBT and BCG or even with cystectomy.
References
Chang SS, Boorjian SA, Chou R, et al. Diagnosis and treatment of non-muscle invasive bladder cancer; unabridged version: American Urological Association (AUA)/Society of Urologic Oncology (SUO) guideline. Linthicum, MD: American Urological Association; 2016 https://www.auanet.org/documents/education/clinical-guidance/Non-Muscle-Invasive-Bladder-Cancer.pdf Accessed August 2, 2017.
Babjuk M, Böhle A, Burger M, et al. EAU Guidelines on non-muscle-invasive urothelial carcinoma of the bladder: Update 2016. Eur Urol. 2017;71:447−61 http://dx.doi.org/10.1016/j.eururo.2016.05.041
Spiess PR et al; NCCN Guidelines Version 5.2017 Panel Members Bladder Cancer. NCCN Clinical Practice Guidelines in Oncology. Bladder Cancer Version 5.2017. Fort Washington, PA: National Comprehensive Cancer Network; 2017 https://www.nccn.org/professionals/physician_gls/pdf/bladder.pdf
Branchereau J, Larue S, Vayleux B, et al. Prognostic value of the lymphovascular invasion in high-grade stage pT1 bladder cancer. Clin Genitourin Cancer. 2013;11:182−8 https://doi.org/10.1016/j.clgc.2012.10.002\
