Shariat - Figure 57
Molecular Pathologic Framework for Risk Stratification of T1 Bladder Cancer
FIG. 57: One promising avenue toward identification of bladder cancer molecular subtypes is the molecular pathologic framework for risk stratification according to 3 molecular subtypes. Different groups, including Swedish researchers,[75] have identified different molecular subtypes similar to those already identified in breast cancer and other cancers. The urobasal, genomically unstable, or squamous-cell carcinoma-like subtypes are present in different groups of patients, according to which patients are seen in any given clinic. T1 disease can be classified into these 3 subtypes, and the high risk of progression associated with the genomic unstable and the squamous-cell carcinoma-like subtypes might indicate that they should be treated more aggressively initially or even be treated with early or immediate radical cystectomy.
References
Patschan O, Sjödahl G, Chebil G, et al. A molecular pathologic framework for risk stratification of stage t1 urothelial carcinoma. Eur Urol. 2015;68:824−32 http://dx.doi.org/10.1016/j.eururo.2015.02.021
