1 - Title Slide 2 - Disclosures 3 - Learning Objectives 4 - Stroke Volume 5 - Stroke Volume (Cont.) 6 - Obstructive and Central Events 7 - Effects on hemodynamics 8 - Effects on CV function 9 - Survival of patients 10 - OSA Adverse Effects 11 - Effect of CPAP 12 - Cumulative Hospitalizations 13 - Other Secondary Outcomes 14 - Transplant-free Survival 15 - CPAP attenuated CSA 16 - Adaptive SERvo-VEntilation 17 - SERVE-HF Trial Results 18 - Primary Endpoint 19 - Secondary Endpoints 20 - Excess Mortality 21 - Trial Conclusion 22 - ADaptive-Servo VENTilation 23 - Non-sleepy patient treatment 24 - Adjusting inspiratory pressure 25 - Protocol 26 - Trial Design 27 - Study Design 28 - Automatic algorithm 29 - Trial Evolution 30 - Trial Evolution (Cont.) 31 - Enrollment by Country 32 - Compliance 33 - Interface Use 34 - Compliance Chart 35 - Applied Pressures 36 - AHI Chart 37 - Baseline Demographic 38 - Baseline Sleep Variables 39 - Cumulative Incidence 40 - Classification 41 - All-Cause Mortality 42 - Interaction Ratio 43 - Comparison of HRs 44 - SDB severity changes 45 - Sleep structure changes 46 - MLHFQ and ESS Chart 47 - NYHA class changes 48 - Potential Effects 49 - Cancer rate comparisons 50 - Did not observe effects 51 - Similar pretrial expectations 52 - Improved QOL and symptoms 53 - Mortality and QOL 54 - EPAP Results 55 - Useful therapy? 56 - HF Treatment Guidelines? 57 - Acknowledgements 58 - Thank You