1 - Title Slide 2 - Disclosures 3 - Covered Topics 4 - Not Covered 5 - Autoimmune Thyroid Disease 6 - Thyroid Autoantibodies 7 - Human TSH Receptor 8 - GPCR 9 - Binding 10 - TSH Signal Transduction 11 - Different Types 12 - Stimulating 13 - Blocking 14 - History 15 - TSHR Autoantibody Assays 16 - Anti-TSHR Nomenclature 17 - ATSHR Nomenclature Cont. 18 - Commercial 19 - Binding Assays 20 - Roche Elecsys 21 - Siemens Immulite TSI Assay 22 - Siemens Immulite Cont. 23 - Functional Antibodies 24 - History of Bioassays 25 - Clinically Available 26 - Examples 27 - Schematic 28 - Experimental Data 29 - Immulite vs Brahms 30 - Automated TRAb Assay? 31 - Highly Variable Sensitivity 32 - Mix Stimulating and Blocking 33 - Mix TSI & TBI 34 - Binding versus Bioassays 35 - Future of Bioassays 36 - Future Continued 37 - Biosensors 38 - Luminescent Biosensor 39 - Bioassays meet Biosensors 40 - Turbo vs Thyretain 41 - Protocols 42 - Characteristics 43 - Thank You!