1 - Title Slide 2 - Endocrinology Consultant 3 - Disclosures 4 - Learning Objectives 5 - Signs of Hyperthyroidism 6 - Thyroid Abnormality 7 - Figure 7 8 - Hyperthyroid vs. Euthyroid 9 - Smoking Exacerbation 10 - Edema and Fibrosis 11 - IgG antibody 12 - Pathogenesis of TED 13 - Orbitopathy 14 - When it's not TED 15 - Early Signs 16 - Lissamine Green 17 - Soft Tissue Involvement 18 - Superior Limbic Keratoconjunctivitis 19 - Lid Retraction 20 - Signs with Lid Retraction 21 - von GRAEFE sign 22 - Kocher Sign 23 - Proptosis 24 - Proptosis – cause & effects 25 - Exophthalmos 26 - Degree of Proptosis 27 - Measurements 28 - Shallow Orbits 29 - Diplopia 30 - Muscle Involvement 31 - Muscle Imaging 32 - Up Gaze Restriction 33 - Optic Neuropathy 34 - Optic Neuropathy Predictors 35 - Visual Acuity Checks 36 - Increased IOP 37 - Rundle's Curve 38 - What to Call It 39 - Clinical Activity Score (CAS) 40 - Mild Disease 41 - Treatment 42 - Medical vs Surgical Therapy 43 - Surgery 44 - Therapeutic Options 45 - Steroids 46 - Steroids (cont.) 47 - Mycophenolate 48 - Rituximab 49 - Tocilizumab 50 - Orbital Radiation 51 - Teprotumumab 52 - Teprotumumab (OPTIC Trial) 53 - Proptosis Reduction 54 - Diplopia Improvement 55 - EOM Shrinkage 56 - Side Effects 57 - IBD and Pregnancy 58 - IV Administration 59 - Treatment of Chronic TED 60 - Thrive-2 Trial 61 - Thrive-2 (Phase 2) 62 - Thrive-2 Phase 3 Studies 63 - Reveal-1 and Reveal-2 64 - Lids Oral Trial 65 - Team 66 - Summary 67 - Thank You