Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

Learning Objectives

Fig. 04 -

What is it?

Fig. 05 -

Pathophysiology

Fig. 06 -

Goblet Cell Hyperplasia

Fig. 07 -

Clinical Importance

Fig. 08 -

Clinical Importance (Cont.)

Fig. 09 -

Clinical Importance (Cont.)

Fig. 10 -

Clinical Importance (Cont.)

Fig. 11 -

CB and Mortality

Fig. 12 -

So What Do We Have?

Fig. 13 -

Pharmacotherapy

Fig. 14 -

Newer Therapies

Fig. 15 -

Effect of Erdosteine

Fig. 16 -

Azithromycin

Fig. 17 -

Roflumilast

Fig. 18 -

Smoking Cessation

Fig. 19 -

Conclusions

Fig. 20 -

Metered Cryospray

Fig. 21 -

Safety and Histological

Fig. 22 -

Inclusion/Exclusion Criteria

Fig. 23 -

Safety and Feasibility Study

Fig. 24 -

Results

Fig. 25 -

Greater improvements

Fig. 26 -

Bronchial Rheoplasty

Fig. 27 -

Inclusion/Exclusion Criteria

Fig. 28 -

Subject Characteristics

Fig. 29 -

Procedure Characteristics

Fig. 30 -

Bronchoscopic Observations

Fig. 31 -

Bronchial Rheoplasty

Fig. 32 -

Histopathology Results

Fig. 33 -

Outcomes

Fig. 34 -

Serious Adverse Events

Fig. 35 -

Improve Airway Count

Fig. 36 -

Reduce Exacerbation Rates

Fig. 37 -

All COPD Symptoms

Fig. 38 -

Current Clinical Trials

Fig. 39 -

Summary and Conclusions

Fig. 40 -

Thank You