Hemodynamic Monitoring for Heart Failure Patients

Academic Content

Program Overview

Faculty Presentations

Introduction Akshay S. Desai MD, MPH William T. Abraham, MD

Faculty Roundtable Discussion

Presentation Notes and References

Current Activity

William T Abraham, MD, FACP, FACC, FAHA, FESC
Director, Division of Cardiovascular Medicine
Professor of Internal Medicine, Physiology and Cell Biology
The Ohio State University Wexner Medical Center
Deputy Director, Davis Heart and Lung Research Institute
The Ohio State University
Columbus, Ohio

Fig. 01 -

Presentation Title

Fig. 02 -

CHAMPION Trial Design

Fig. 03 -

PAP Measurement System

Fig. 04 -

CHAMPION PA Target Pressures

Fig. 05 -

Clinical outcomes

Fig. 06 -

PAP-M: Reduces hospitalizations

Fig. 07 -

PAP-M: Benefits and comorbidities

Fig. 08 -

PAP-M: Better than GDMT

Fig. 09 -

PAP-M: Lowers mortality

Fig. 10 -

CHAMPION lowers 30-day readmissions

Fig. 11 -

CHAMPION: Effect on CMS HRRP

Fig. 12 -

CHAMPION: Longitudinal analysis(1)

Fig. 13 -

CHAMPION: Longitudinal analysis(2)

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The American Journal of Cardiology

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Abraham - Figure 9

Impact of PAP-Guided HF Management on All-Cause Mortality in GDMT Population

In addition to the further reduction in hospitalizations discussed in Figure 8, this analysis also suggested that PAP-guided management could produce a reduction in the risk of mortality. As shown in Figure 9,^[10] a 43% relative risk reduction (57% hazard ratio) for patients treated with PAP-guided HF management in addition to GDMT provides a strong suggestion that a reduction in HF hospitalizations with PAP-guided HF management may also result in a reduction in mortality. However because this was a retrospective analysis of a subgroup of the CHAMPION population, this information cannot be taken as definitive.

Abraham WT. Am J Cardiol. 2015; 00.

References

[10]

Abraham WT, Adamson P, Stevenson L, et al. Pulmonary artery pressure management in heart failure patients with reduced ejection fraction significantly reduces heart failure hospitalizations and mortality above and beyond background guideline-directed medical therapy. J Am Coll Cardiol. 2015;65(10S):A790.

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