Lotan - Figure 8
Marker Sensitivity and Specificity: Meta-analyses
FIG. 8: There are several meta-analyses analyzing the sensitivity and specificity of available biomarkers. Overall several common themes are evident. Cytology has an inferior sensitivity but a superior specificity compared to commonly available urine biomarkers. While this not an all-inclusive list, it is clear that most urine biomarkers have a better sensitivity, overall, than cytology, but their specificity is inferior by 10-20%.
References
Shariat SF, Karam JA, Lotan Y, Karakiewicz PI. Critical evaluation of urinary markers for bladder cancer detection and monitoring. Rev Urol 2008;10:120–35
Tilki D, Burger M, Dalbagni G, et al. Urine markers for detection and surveillance of non-muscle-invasive bladder cancer. Eur Urol. 2011;60:484−92 http://dx.doi.org/10.1016/j.eururo.2011.05.053
