Other considerations when presented with a patient with possible T2DM include gender, ethnic and racial variation, as well as genetic differences.[2] Little is known about some of the possible genetic differences.  It is known that type 2 diabetes is a polygenic form of chronic disease, meaning that there are many places in the genetic spectrum where the genesis of a patient’s diabetes may fall.  For example, there is more insulin resistance among Latinos, whereas East Asians have more β-cell dysfunction.  Gender may also correlate with concerns about adverse events; for example, bone loss from treatment with thiazolidinediones (TZDs) is of more concern among older female patients, simply because these patients are at increased risk of osteopenia or osteoporosis.  Kapustin J. J Nurse Pract. 2014; 00:00 – 00.