Stenzl - Figure 31
The Mechanism of Action of Checkpoint Inhibition
FIG. 31: Checkpoint inhibition is based on the concept that the tumor cell tries to reduce the activity of infiltrated T-cells acting on the tumor cell by blocking either the PD-L1 receptor or the programmed cell death protein 1 (PD1) receptor on the T-cell.[21]
References
[21]
Powles T, Smith K, Stenzl A, Bedke J. Immune checkpoint inhibition in metastatic urothelial cancer. Eur Urol. Published online April 13, 2017 http://dx.doi.org/10.1016/j.eururo.2017.03.047
